| 03/11/2025 | Lawrence North | Varsity | 6:30PM - 8:30PM | Center Grove High School / Lacrosse Field | |
| 03/13/2025 | Varsity | Guerin | 7:30PM - 9:30PM | Guerin Catholic High School / Lacrosse Field | |
| 03/15/2025 | Varsity | Penn | 12:45PM - 2:45PM | Penn High School / Lacrosse Field | Rescheduled |
| 03/15/2025 | Varsity | Northridge | 3:45PM - 5:45PM | Penn High School / Lacrosse Field | Rescheduled |
| 03/16/2025 | Varsity | Crown Point | 9:15AM - 11:15AM | St. Joseph High School / Football Stadium | Rescheduled |
| 03/16/2025 | Varsity | St. Joseph | 12:30PM - 2:30PM | St. Joseph High School / Football Stadium | Rescheduled |
| 03/18/2025 | Carmel | Varsity | 7:30PM - 9:30PM | Center Grove High School / Lacrosse Field | |
| 03/20/2025 | Varsity | HSE | 7:30PM - 9:30PM | Hamilton Southeastern High School / Lacrosse Field | |
| 04/05/2025 | Evansville Memorial | Varsity | 12:30PM - 2:30PM | Center Grove High School / Lacrosse Field | |
| 04/08/2025 | Varsity | Cathedral | 7:30PM - 9:30PM | Cathedral High School / Lacrosse Field | |
| 04/10/2025 | Varsity | Brebeuf | 6:00PM - 8:00PM | Marian University / Football Field | |
| 04/19/2025 | Evansville North | Varsity | 12:25PM - 2:25PM | Center Grove High School / Lacrosse Field | |
| 04/26/2025 | Dupont Manual | Varsity | 10:15AM - 12:15PM | Center Grove High School / Lacrosse Field | |
| 04/29/2025 | Varsity | Lawrence North | 6:30PM - 8:30PM | Lawrence North High School / Turf Field | |
| 05/05/2025 | Bishop Chatard | Varsity | 7:30PM - 9:30PM | Center Grove High School / Lacrosse Field | |
| 05/06/2025 | Noblesville | Varsity | 7:30PM - 9:30PM | Center Grove High School / Lacrosse Field | |